Project description
In this project we will develop the catalytic enantioselective oxa-Michael reactions of water, alcohols and phenols as nucleophiles on α,β-unsaturated aldehydes, ketones and carboxylic acids from renewable resources. These transformations will be achieved using our recently developed concept of DNA-based asymmetric catalysis. In this concept a DNA-based catalyst, so a catalyst from a renewable source, is assembled in a modular fashion by binding a non-chiral transition metal catalyst to the DNA using non-covalent interactions. This new catalytic approach is expected to give access to highly valuable chiral intermediates for fine chemical and farmaceutical applications.
In this project we will develop the catalytic enantioselective oxa-Michael reactions of water, alcohols and phenols as nucleophiles on α,β-unsaturated aldehydes, ketones and carboxylic acids from renewable resources. These transformations will be achieved using our recently developed concept of DNA-based asymmetric catalysis. In this concept a DNA-based catalyst, so a catalyst from a renewable source, is assembled in a modular fashion by binding a non-chiral transition metal catalyst to the DNA using non-covalent interactions. This new catalytic approach is expected to give access to highly valuable chiral intermediates for fine chemical and farmaceutical applications.
Requirements
The candidate should have a MSc or equivalent degree in synthetic chemistry, with excellent laboratory skills and a strong desire to work in a highly interdisciplinary environment.
Conditions of employment
A Ph.D. Scholarship at the Stratingh Institute for Chemistry and the Institute for Technology, Engineering & Management at the University of Groningen will be provided for four years. Assistance with stay permits in the Netherlands for non- EU citizens will be provided by the university.
Applications
Please send your applications including curriculum vitae and the names and contact information of at least two references before January 15th to:
Personnel Department
University of Groningen
P.O.Box 72
9700 AB GRONINGEN
The Netherlands
E-mail: vmp@bureau.rug.nlAdditional information
Supervisors: dr. J. G. Roelfes (homepage), prof. dr. J. G. de Vries and prof. dr. B. L. Feringa.
Contact: prof. dr. J.G. Roelfes